LATS1-Beclin1 mediates a non-canonical connection between the Hippo pathway and autophagy
Understanding the mechanisms of evasive resistance in cancer is of great importance to develop efficient therapies.Analyzing the molecular mechanisms underlying therapy resistance of hepatocellular carcinoma Drug Tests (HCC), we have discovered a kinase-activity independent role of LATS1 (large tumor suppressor) but not LATS2 in regulating sorafeni